Acetyl-l-Carnitine Molecular Structure
Acetyl-l-Carnitine benefits health by functioning as a powerful antioxidant in the body that enhances the production of Glutathione, one of the body’s natural master antioxidants. Acetyl-l-Carnitine or ALC boosts both physical and mental energy by increasing ATP production in the mitochondria of all cells. ALC readily passes the blood-brain barrier and thus it is useful for treating Alzheimer’s dementia, depression and cognitive impairment in the elderly. Vegetarians and vegans take note that the primary natural source of ALC is red meat which means supplementation is almost required for optimal brain function.
It has only been in the past decade where the mainstream medical establishment has recognized the value of supplementing with Acetyl-l-Carnitine. This quote from The National Institute of Health supports this shift in thinking: “A large body of evidence points to the positive effects of dietary supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in neuroinflammation, which is a common denominator in a host of neurodegenerative diseases. ALC is the principal acetyl ester of L-Carnitine (LC), and it plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facilitating the transfer of fatty acids from cytosol to mitochondria during beta-oxidation. Dietary supplementation of ALC exerts neuroprotective, neurotrophic, antidepressive and analgesic effects in painful neuropathies. ALC also has antioxidant and anti-apoptotic activity. Moreover, ALC exhibits positive effects on mitochondrial metabolism, and shows promise in the treatment of aging and neurodegenerative pathologies by slowing the progression of mental deterioration. In addition, ALC plays neuromodulatory effects on both synaptic morphology and synaptic transmission. These effects are likely due to affects of ALC through modulation of gene expression on several targets in the central nervous system. Here, we review the current state of knowledge on effects of ALC in the nervous system.”
The Health Benefits of Acetyl-l-Carnitine:
AGING PROCESS
• Helps to prevent the age-related decline of Glucocorticoid Receptors in the Brain.
• Lipofuscin deposits in the Heart and Brain may be significantly reduced by supplementation.
• Helps to retard age-related damage to Neurons in the Brain.
• May inhibit the increase in size of Adipocytes in Subcutaneous Tissue that occurs as a result of Aging.
• Retards damage to Mitochondrial DNA as a result of Aging.
• Helps to prevent the natural decline of NMDA Receptors (N-Methyl-D-Aspartate Receptors) that occurs as a result of aging.
CARDIOVASCULAR SYSTEM
• Reaction time of Cerebral Insufficiency patients can be improved with supplementation.
• May significantly reduce Lipofuscin deposits in the Heart and may improve Mitochondrial function.
• May lower High Blood Pressure (Hypertension).
• Walking distance in Intermittent Claudication patients may be improved by supplementation.
• Can reduce the toxic effect of Ischemia on the Brain.
• May help to protect the Brain from many of the toxic after-effects of Stoke.
DETOXIFICATION
• Protects Neurons from the excitotoxic effects of excess Glutamic Acid.
• May protect cell against the toxic effects of Gamma-Rays.
• Can prevent MPTP-induced damage to dopaminergic Neurons.
• Reduces Neurotoxicity of N-Methyl-D-Aspartate (NMDA).
• Helps protect Neurons from the toxic effects of Ammonia.
• Damage to the Brain, Heart, Kidneys, Stomach and Liver by Alcohol may be mitigated by supplementation.
• May counteract Ecstasy-induced damage to NMDA Receptors.
DIGESTIVE SYSTEM
• Can inhibit the ability of Alcohol to cause Gastric Ulcers.
• May help to prevent Pancreatitis.
HEARING & VISION
• Can improve Age-Related Hearing Loss by improving the function of Mitochondria in the Ear’s Cochlea.
• May help to prevent Noise-Induced Hearing Loss.
• Age-Related Macular Degeneration (ARMD) may be improved by supplementation.
• May prevent Cataracts by preventing simple sugars from Cross-Linking (glycosylation) proteins within the Eyes.
• Glaucoma may be prevented/treated by supplementation.
• Protects the Optic Nerve from Glycosylation.
• May prevent the loss of sight associated with the Retinal damage of Retinopathy and Diabetic Retinopathy.
IMMUNE SYSTEM
• Helps to preserve White Blood Cell count in Acquired Immune Deficiency Syndrome (AIDS) patients.
• Stimulates the Immune System.
• Increases Macrophage and Phagocyte activity.
METABOLISM
• A potent Antioxidant.
• Increases endogenous Glutathione production.
• Improves Athletic Performance.
• May increase Insulin-like Growth Factor (IGF-1).
• Enhances ATP production.
• Elevated Blood Sugar can be reduced by supplementation.
• May lower total Serum Cholesterol Levels.
• Chronic Fatigue Syndrome patients may experience an increase in energy levels with supplementation.
• Prevents Glycosylation (Cross-Linking) of the body’s endogenous proteins by Simple Sugars.
• Function of the Electron Transport System (ETS) is improved by supplementation due to its enhancement of Cytochrome C Oxidase activity.
• Useful in the treatment of Diabetes Mellitus Type 1.
• Glucose disposal in Diabetes Mellitus Type 2 patients is improved by supplementation.
• Enhances Energy Production in every cell of the body by mobilizing Short and Medium-Chain Fatty Acid across Cell Membranes enabling them to be used by the Mitochondria.
• When taken prior to Exercise, improves Athletic Performance.
• Fatigue may be eliminated by supplementation.
• Improves Stamina.
• Can limit the damage from Hypoxia.
• Stress- induced Cortisol levels may be reduced by supplementation.
• May lower elevated Leptin and reduce Leptin Resistance.
MUSCULOSKELETAL SYSTEM
• May improve pain levels and mental health in Fibromyalgia patients.
NERVOUS SYSTEM
• May improve Age Associated Memory Impairment (AAMI) also improving Mood and Creativity.
• Alcohol Withdrawal Syndrome may be prevented/treated with supplementation.
• Helps to prevent the deterioration of Mental Function in Alzheimer’s Disease patients and may retard the progression of the disease.
• Alertness, Attention Span and Short Term Memory in Alzheimer’s Disease patients may be improved with supplementation.
• Reduces the toxicity of Amyloid-Beta Protein to Neurons.
• Due to its ability to improve the function of Motor Neurons, it may be useful in the treatment of Amyotrophic Lateral Sclerosis (ALS).
• Helps treat Anxiety and Depression especially in the elderly.
• Impulsivity in Attention Deficit/Hyperactivity Disorder (ADHD) patients may be reduced by supplementation.
• May facilitate the recovery from Coma.
• Attention Span in Down’s Syndrome patients may be improved by supplementation.
• Useful in the treatment of Alcohol Dependence due to its ability to reduce cravings and withdrawal symptoms.
• Recovery from Hemiplegia (paralysis of one side of the body) may be accelerated by supplementation while improving Mood and Attention Span.
• Due to its ability to prevent damage to the Myelin Sheath of Nerves, may be useful in the treatment of Multiple Sclerosis (MS).
• Improves symptoms of Neuropathy (all types).
• The pain from Sciatica may be reduced by supplementation.
• May help to resolve Facial Paralysis.
• Currently being researched as a possible treatment for Parkinson’s Disease.
• The damaging effects of excessive Stress may be mitigated by supplementation.
• May be useful in the treatment of Spinal Cord injuries.
• Supplementation improves Alertness and Attention Span.
• Can improve Eye to Hand Coordination by up to 400%.
• Enhances Learning ability.
• Both Short and Long Term Memory as well as Spatial Memory are improved by supplementation.
• Improves Mood and is useful in the treatment of Mood Disorders.
• Sleep quality can be improved with supplementation.
• Can help to normalize Circadian Rhythm.
• Taken early in the day, may increase night time Melatonin production.
• Can improve Verbal Fluency.
• Helps to prevent the age-related decline of and damage to: Dopamine, Cholinergic, NMDA, NGF and Glucocorticoid Receptors.
• Enhances both Dopamine release and function.
• Stimulates both the production and release of Acetylcholine.
• Beta-Endorphin levels may be normalized by supplementation.
• May facilitate the regeneration of Cranial Nerves after injury.
• All aspects of age-related decline of the Brain are retarded by supplementation.
• Stimulates and maintains the growth of Neurons and Axons in the Brain and helps prevent the death of existing Neurons.
• Helps reduce the Age-Related decline of Nerve Growth Factor (NGF).
SEXUAL SYSTEM (Male)
• Can prevent/treat Male Impotence.
• Male Infertility may be alleviated by supplementation.
• Supplementation may alleviate Peyronie’s Disease.
• May enhance the function of Sertoli Cells.
• Can increase testosterone in men.
USAGE
ALC should be taken at least one hour before meals on an empty stomach for maximum benefit. Do not take ALC in the evening as it may interfere with sleep. Normal dosages for people without cognitive impairment range from 500-1,500mg per day. Therapeutic dosages for those with Alzheimer’s Disease range from 2,500-3,000mg per day. ALC should not be taken by children and pregnant or lactating women without the supervision of a qualified practitioner.
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