Quercetin Molecular Structure
Quercetin is a Flavonol Bioflavonoid found in many fruits, vegetables and grains such as red wine, onions, green tea, apples and buckwheat. Quercetin is taken orally for conditions of the heart, blood vessels, arthritis, diabetes and to help regulate certain hormones. Quercetin benefits the body by exerting powerful anti-aging properties as well as powerful anti-inflammatory properties helping to reduce inflammation, control blood sugar and to prevent heart disease and cancer.
The Health Benefits of Quercetin:
CARDIOVASCULAR SYSTEM
• May prevent Atherosclerosis.
• Helps to protect against Cardiovascular Diseases.
• Hastens recovery from Heart Attack.
• Helps to lower High Blood Pressure.
• Inhibits Abnormal Blood Clotting.
• May prevent Stroke and Thrombosis.
• Reduces the production of C-Reactive Protein.
DETOXIFICATION
• May inhibit the toxicity of Arsenic.
• Reduces the ability of Cadmium to damage the Kidneys.
• Helps to remove excess Iron from the body.
• May facilitate the removal of Lead from the Brain and reduce its toxicity.
• Helps to reduces the toxicity of Mercury.
• Quercetin helps to protect the body from the toxic effects of Drugs such as:
▪ Cisplatin
▪ Doxorubicin
▪ Gentamicin
▪ Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
▪ Paracetamol
▪ Tamoxifen (may improve effectiveness)
DIGESTIVE SYSTEM
• Helps to lessen the symptoms of Celiac Disease.
• May be an effective treatment for Diarrhea.
• Protects the Gastric Mucosa from the damage induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDS).
• May prevent/treat Gastric Ulcers.
EARS / EYES
• May inhibit Otosclerosis.
• By inhibiting Aldose Reductase, helps to prevent Cataracts.
• Prevents Lipid Peroxidation in the Retina.
EXCRETORY SYSTEM
• Can prevent/treat Diabetic Nephropathy.
• Supplementation may prevent Kidney Stones.
• Due to its Antioxidant Properties, it protects the Kidneys from Free Radicals.
HORMONES / ENZYMES
• By inhibiting Aromatase, lowers Estradiol (E2) levels.
• Can enhance Insulin secretion.
• May stimulate the release of Adiponectin.
• Inhibits Angiotensin 2 production.
• May inhibit Platelet Aggregating Factor (PAF).
• Inhibits Collagenase activity.
• 5-Lipoxygenase (5-LOX) activity is inhibited by supplementation.
IMMUNE SYSTEM
• Quercetin is a highly effective Antihistamine.
• Inhibits Histamine, Pro-Inflammatory Cytokines, Leukotrienes, Prostaglandin E2 (PGE2) and Interleukin-4 (IL-4) production.
• May lower elevated levels of Interleukin 6 (IL-6).
• Can prevent Anaphylaxis from Food Allergies.
• Has significant antitumor activity and may be effective against the following forms of Cancer:
▪ Brain
▪ Breast
▪ Cervical
▪ Colon
▪ Endometrial
▪ Esophageal
▪ Gliomas
▪ Kidney
▪ Laryngeal
▪ Leukemia
▪ Liver
▪ Lung
▪ Melanoma
▪ Mesothelioma
▪ Oral
▪ Osteosarcoma
▪ Ovarian
▪ Pancreatic
▪ Prostate
▪ Squamous Cell Carcinoma
▪ Stomach
• Reduces Inflammation by inhibiting Histamine release.
• Stabilizes membranes of Mast Cells causing them to become less reactive to Antigens that cause Allergies and decreases their ability to release Histamine and Serotonin.
• Inhibits many forms of Detrimental Bacteria such as:
▪ Helicobacter pylori
▪ Staphylococcus aureus
▪ Escherichia coli
▪ Shigella flexneri
▪ Proteus vulgaris
▪ Pseudomonas aeruginosa
▪ Lactobacillus casei var shirota
• Inhibits many forms of Detrimental Fungi including Candida albicans.
• Exhibits significant Anti-Viral effects and may be effective against such viruses as:
▪ Rhinovirus (Common Cold)
▪ Cytomegalovirus
▪ Epstein-Barr
▪ Hepatitis C
▪ Herpes Simplex 1 & 2
▪ HIV (by inhibiting Viral Reverse Transcriptase enzyme)
▪ Influenza
▪ MERS (a type of Coronavirus)
▪ Parainfluenza
▪ Picornavirus
▪ Polio
▪ Respiratory Syncytial Virus
▪ SARS (a type of Coronavirus)
• Stimulates the activity of NK Lymphocytes (Natural Killer Cells)
• May increase Interferon Gamma production.
• Inhibits the excessive production of Tumor Necrosis Factor (TNF-alpha).
METABOLISM
• Possesses powerful Antioxidant properties.
• Helps to stabilize Cell Membranes.
• Inhibits Lipid Peroxidation.
• Helps activate Glutathione Peroxidase an Endogenous Antioxidant Enzyme.
• Neutralizes Hydrogen Peroxide-induced Free Radicals.
• Effective scavenger of Superoxide Free Radicals.
• Recycles Glutathione.
• May preserve the integrity of Beta Cells in the Pancreas (important for Diabetes Type 2 sufferers) and may actually help to prevent Diabetes.
• Total Cholesterol Profile is positively affected by supplementation as it Lowers Total Cholesterol, Increases HDL Cholesterol (good Cholesterol) and Lowers LDL Cholesterol (bad Cholesterol) while also inhibiting its oxidation.
• May treat/prevent Cirrhosis.
• Can inhibit the ability of certain Toxins such as Carbon Tetrachloride and Paracetamol to damage the Liver.
• May help stop damage to the Pancreas that occurs in Pancreatitis by suppressing Leukotriene B4.
• Athletic Performance and Stamina may be enhanced by supplementation.
• Inhibits the Cross-Linking of proteins.
• Useful in the treatment of Obesity.
• May reduce Edema (water retention).
MUSCULOSKELETAL SYSTEM
• By inhibiting Xanthine Oxidase, helps to alleviate Gout.
• May induce apoptosis (cellular death) of Osteoclasts (bone reabsorbing cells) thereby helping to prevent Osteoporosis.
• Due to its anti-inflammatory properties, it is useful in the treatment of Rheumatoid Arthritis.
NERVOUS SYSTEM
• May help to prevent Age Associated Memory Impairment.
• May help to alleviate the Anxiety and Convulsions associated with Alcohol Withdrawal Syndrome.
• By inhibiting the formation of Amyloid-Beta Protein and destabilizing existing Amyloid-Beta Protein, it may be useful in the prevention and treatment of Alzheimer’s Disease.
• By activating GABAa Receptors, helps to alleviate Anxiety.
• May aid in alleviating Depression.
• Alcohol-Induced Memory Impairment may be prevented by supplementation.
• Helps protect the Brain against Multiple-Infarct Dementia.
• Useful in Pain Management.
• Promotes Slow Wave Sleep.
• Recovery from Spinal Cord Injury may be facilitated by supplementation.
ORAL HEALTH
• Retards the progression of Periodontal Disease.
RESPIRATORY SYSTEM
• Due to its Anti-Inflammatory properties, supplementation helps alleviate the symptoms of Asthma.
• Its Anti-Histamine effects make it useful for the treatment of Allergic Rhinitis, Hay Fever and Perennial Allergic Rhinitis.
• May help to treat and or prevent Chronic Obstructive Pulmonary Disorder (COPD) by inhibiting the production of Interleukin 8 (IL-8).
• Helps prevent Respiratory Tract Infections.
• Chronic Sinusitis may be alleviated by supplementation.
SEXUAL SYSTEM (Female)
• By inhibiting Aromatase, lowers Estradiol (E2) levels.
• Increases Nitric Oxide Synthase activity.
SEXUAL SYSTEM (Male)
• Male Infertility may be helped by supplementation.
• Reduces the Inflammation associated with Prostatitis.
• By inhibiting Aromatase, lowers Estradiol (E2) levels.
• Increases Nitric Oxide Synthase activity.
SKIN
• By inhibiting excess Histamine, it is useful in the treatment of Hives.
• Inhibits the Lipoxygenase pathway of Arachidonic Acid making it useful for treating Psoriasis.
• Helps to minimize Scarring.
Health Conditions Improved by Quercetin Supplementation
USAGE
Therapeutic dosages of Quercetin range from 600-3,000mg daily. Vitamin C functions synergistically with Quercetin and enhances its efficacy. The average half-life of Quercetin is 25 hours. When choosing a Quercetin supplement, choose one with a deep rich yellow color. It was originally believed that Quercetin was poorly absorbed orally. However, new research shows that absorption is greatly enhanced when ingested with dietary fats, thus, it is best taken with meals. If you are unable to take Quercetin with a fat containing meal due to dietary restrictions, you can increase its absorption by combining it with Bromelain. Taking Quercetin with the enzyme Bromelain increases its efficacy.
Quercetin Content of Foods
My Personal Recommendations:
Combine Quercetin with Bromelain to Increase Efficacy
Quercetin & Bromelain – 400/82.5mg
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