Vinpocetine Molecular Structure
Vinpocetine is derived from an extract of the seeds of the common lesser Periwinkle plant (Vinca minor). Vinpocetine has been used medicinally in Europe for over 40 years to treat a number of Cerebrovascular diseases. Vinpocetine benefits the Brain by improving circulating oxygen levels aiding in overall health and function. This is a tremendous benefit of supplementation as the brain is incapable of Anaerobic Metabolism. This means that even brief interruptions in oxygen supply can cause immediate damage to the Brain. Because of its ability to increase oxygen levels in the Brain it is very useful in treating Brain disorders such as Stroke, Dementia, Alzheimer’s Disease, Cognitive decline and the like. More recently it has been investigated as a Nootropic or “Smart Drug” due to its positive impact on learning, memory and focus. Vinpocetine has an excellent safety profile with few potential side effects. These side effects occur in less than 1% of the people who use Vinpocetine.
Many older adults have some level of Cerebral Vascular Disease which leads to Chronic Cerebral Vascular Ischemia. In this case, blood is still getting to all areas of the brain but some regions to not receive optimal blood flow. When this occurs, we begin to see signs of Dementia, Cognitive Decline and other symptoms that may mimic other Brain conditions. Researchers have used PET scans and Transcranial Doppler Ultrasound to demonstrate that Vinpocetine supplementation increases Brain glucose uptake as well as improving blood flow to deficient areas. If you have a family history of any Brain disorder that could stem from Chronic Vascular Cerebral Insufficiency, you may want to consider supplementation with Vinpocetine long before any symptoms occur.
The Health Benefits of Vinpocetine:
AGING PROCESS
• May significantly decrease the decline in Dopamine that normally occurs in the aging Brain.
CARDIOVASCULAR SYSTEM
• Improves Blood Circulation to the Brain.
• Useful in the treatment and prevention of Cerebral Insufficiency.
• Acts as a Vasodilator.
• Can reduce Blood Pressure.
• Improves the elasticity of Red Blood Cells and thereby may help to prevent Strokes.
• May help to lower elevated Hematocrit.
DIGESTIVE SYSTEM
• May inhibit Inflammation of the Stomach and Gastric Mucosa caused by excessive Alcohol intake.
HEARING
• May improve Deafness in cases of sudden hearing loss.
• Helps treat cases of Sensorineural Hearing Loss.
• By improving Blood Circulation may help to resolve problems of the Inner Ear.
• May alleviate symptoms of Meniere’s Disease.
• Reduces symptoms of Tinnitus (Ringing in the Ears).
• Can alleviate Vertigo in 77% of patients.
EXCRETORY SYSTEM
• Urinary Incontinence may be relieved with supplementation.
IMMUNE SYSTEM
• Due to its vasodilating properties, reduces Inflammation.
METABOLISM
• Helps prolong survival during periods of Anoxia (complete absence of Oxygen).
• Comparable to Vitamin E in its Antioxidant potential.
• Deactivates Hydroxyl Free Radicals.
• Alleviates Fatigue when Fatigue is due to Cerebral Insufficiency.
• Helps counteract the toxic effects of Ischemia on Neurons.
• Due to its Antioxidant effect, protects Hyaluronic Acid from damage.
NERVOUS SYSTEM
• By improving Oxygen and Glucose utilization in the Brain, helps to increase Alertness.
• Helps relieve Altitude Sickness by improving Oxygen utilization.
• May be useful in the treatment of Alzheimer’s Disease.
• By improving Blood Circulation and Oxygen delivery to the Brain, may help prevent Amnesia.
• Reduces Anxiety when Anxiety is caused by Cerebral Insufficiency.
• Alleviates Cerebral Insufficiency and its side effects by selectively dilating Cerebral Arteries thus improving Circulation to the Brain.
• Increases Adenosine Triphosphate (ATP) within Brain Neurons increasing Brain Energy production.
• May prevent and treat Multiple-Infarct Dementia.
• Helps reduce Confusion when related to Cerebral Insufficiency.
• When Depression results from Cerebral Insufficiency, Vinpocetine is 74% effective in alleviating said Depression.
• Fear, Phobias and Stage Fright are helped by supplementation when related to Cerebral Insufficiency.
• Up to 78% of Headache sufferers find relief from supplementation.
• Has been known to alleviate Speech Impairment in up to 55% of cases.
• By improving the Brain’s use of Oxygen, may prevent and treat Stroke.
• May prevent Travel Sickness.
• Can alleviate Vertigo in some patients.
• May improve coordination by improving Blood Circulation to the Brain.
• Shown to accelerate the rate of learning by up to 40%
• Helps improve Memory in normal, healthy people.
• Shown to improve Short Term memory in as little as one hour after ingestion.
• Helps to improve Long Term Memory due to its enhancement of Blood Circulation to the Brain.
• Helps protect Astrocytes from damage during periods of Hypoxia (Low Oxygen).
• Concentrates in the Basal Ganglia and Occipital Lobe of the Brain.
• May improve functions of the Brain that reside in the Brain Stem.
• Enhances functioning of the Hippocampus and Denate Gyrus region of the Hippocampus.
• Helps increase the Brain’s tolerance to Hypoxia by promoting Oxygen transport into Brain tissue.
• Improves function and increases activity of the Locus Coeruleus region of the Brain Stem.
• Its Antioxidant effects protect Neurons from damage.
• Helps counteract the toxic effects of Ischemia on Neurons.
• Helps increase the Brain’s utilization of Glucose and shift Glucose metabolism towards the more favorable aerobic pathway.
• Reduces the decline in Dopamine that occurs in tandem with Aging.
• Can raise Serotonin levels.
• Can improve Norepinephrine turnover in the Brain.
RESPIRATORY SYSTEM
• May help to reduce Lung Inflammation in Chronic Obstructive Pulmonary Disease (COPD) patients.
• May enhance the release of Oxygen from Hemoglobin.
SEXUAL SYSTEM (Female)
• The symptoms of Menopause may respond to supplementation, especially during early Menopause.
TOXINS
• Helps protect Neurons from damage caused by excessive levels of Glutamic Acid.
• Inhibits Phosphodiesterase-1 (PDE-1).
• Facilitates excretion of Aluminum and Lead from the body.
• Reduces neurotoxic effects of N-Methyl-D-Aspartate (NMDA).
• May help counteract some of the toxic effects of Alcohol on the Brain.
• May inhibit the ability of Alcohol to cause Stomach Inflammation.
VISION
• By improving Blood Circulation to the Eyes may help to improve the condition of Age-Related Macular Degeneration (ARMD) patients.
•Improves Blood Circulation to the Retina and Macula.
• May help to stabilize Glaucoma.
• May improve Night Blindness.
• Can improve Sight in patients with Eye Disorders related poor Blood Circulation.
USAGE
Vinpocetine is absorbed rapidly through the small intestine with blood levels reaching peak just 90 minutes after ingestion. Vinpocetine readily crosses the Blood-Brain Barrier, dilating blood vessels and improving oxygen levels and utilization. Consuming with food increases absorption up to 60% compared to only 7% when taken without food.
Most clinical trials using Vinpocetine have used doses between 10 and 40mg daily. In all cases, dosages of 30mg daily exerted superior therapeutic effects compared to lower dosages. It is important to note that doses over 40mg daily showed no additional therapeutic effects. Thus, 40mg should be considered the maximum daily dose. Maximum Memory improvement occurred at 40mg daily. It is recommended to start with a lower dose (10mg) and to work your way up to the desired dose over a period of several weeks. The therapeutic effects of Vinpocetine can begin to manifest themselves after two days of supplementation with maximum benefit being achieved after one year.
CAUTIONS:
• May occasionally cause a transient drop in Blood Pressure. People with Hypotension (Low Blood Pressure) should start slow and monitor their pressure.
• Rarely may cause transient Tachycardia.
• Rarely causes Dry Mouth.
CONTRAINDICATIONS:
• Women should not use Vinpocetine during Pregnancy.
Periwinkle (Vinca minor)
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