Pregnenolone Molecular Structure
Pregnenolone is an endogenous Steroid Hormone that is produced primarily in the Adrenal Glands. It is also classified as a Neurosteroid or Neurohormone. Pregnenolone is often referred to as the “Mother Hormone” as it is a precursor for many hormones in the body such as the sex steroid hormones (Testosterone, Estrogen and Progesterone), mineralocorticoids (which regulate mineral and fluid balance) and glucocorticoids (which regulate sugar and certain aspects of the immune system).
A 75 year old person produces about 60% less Pregnenolone than a 35 year old and a 90 year old person produces 95% less than a 30 year old! Thus, it is believed that Pregnenolone possesses Life Extension properties. Pregnenolone concentrates in the Brain and low levels of Pregnenolone in the aged are implicated in diseases of aging brain such as Dementia and Alzheimer’s.
Pregnenolone has the following health benefits:
AGING
• Pregnenolone production declines in tandem with the Aging Process. Supplemental Pregnenolone may help to counteract certain aspects of the Aging Process.
• Pregnenolone is believed to have Life Extension properties.
HEARING & VISION
• Supplemental Pregnenolone may improve Hearing ability.
• Pregnenolone concentrates in the Retina and helps protect the Retina from the damaging effects of Excitotoxins.
• People using supplemental Pregnenolone have reported improvements in Eyesight.
IMMUNE SYSTEM
• Pregnenolone may help to prevent certain types of Cancer.
• Certain aspects of the Immune System are enhanced with Pregnenolone supplementation.
• Inflammation is suppressed by Pregnenolone.
• Pregnenolone has shown benefit to Lupus Erythematosus at dosages of 50 – 600mg per day.
METABOLISM
• The Beta Cells of the Pancreas may be rejuvenated in Diabetes Mellitus Type 1 with supplemental Pregnenolone.
• Subjective feelings of Energy may be improved by Pregnenolone.
• Pregnenolone may prevent Fatigue.
• Exophthalmia (protrusion of the Eyes) in Graves Disease patients can be resolved with Pregnenolone supplementation.
• Pregnenolone may stimulate Weight Loss in those afflicted with Obesity.
• Pregnenolone can improve Stamina in those suffering from chronic Stress.
• Total serum Cholesterol may be reduced by supplemental Pregnenolone.
• Pregnenolone may increase the production of Human Growth Hormone (hGH).
MUSCULOSKELETAL SYSTEM
• Osteoarthritis patients may benefit from supplemental Pregnenolone.
• Due to its conversion to Progesterone within the body, Pregnenolone is useful in the treatment of Osteoporosis.
• After its discovery, Pregnenolone was the primary treatment for Rheumatoid Arthritis. When used for this purpose, Pregnenolone is most effective when used in early stages of the disease.
• Scleroderma patients may benefit from supplemental Pregnenolone.
NERVOUS SYSTEM
• People afflicted with Alzheimer’s Disease and other forms of Dementia have been shown to have low levels of Pregnenolone.
• Pregnenolone may be useful in the treatment of Anxiety and other Anxiety-related ailments such as Obsessive-Compulsive Disorder (OCD) and Panic Disorder.
• Depression may be alleviated by Pregnenolone, especially when the Depression is caused by high Cortisol levels.
• Pregnenolone may be useful in the treatment of Manic Depression during both the Manic and Depression states.
• Pregnenolone may be an effective treatment for Multiple Sclerosis.
• Schizophrenia may be alleviated by Pregnenolone.
• Pregnenolone is currently being investigated as a treatment for preventing or reversing Paralysis in Spinal Cord injury.
• The body’s ability to handle Stress may be enhanced by Pregnenolone.
• Pregnenolone enhances certain aspects of the Nervous System such as:
▪ Alertness
▪ Hand-to-Eye Coordination
▪ Creativity
▪ Intelligence
▪ Learning ability
▪ Memory (Long Term & Short Term)
• Pregnenolone is involved in many aspects of neuronal synchronization required for optimal Mental Performance.
• The Memory-impairing effects of Alcohol are inhibited by Pregnenolone.
• Spatial Memory may be improved by Pregnenolone.
• Mood and Mood Disorders may be improved by Pregnenolone.
• Subjective reports of increased feelings of Happiness have been reported with supplemental Pregnenolone.
• Pregnenolone may be useful in the treatment of Social Anxiety, Phobias and Stage Fright as these patients have been shown to have low serum Pregnenolone levels.
• Low dose Pregnenolone has been shown to improve Sleep quality by reducing the number of awakenings during Sleep and by increasing the amount of time spent in Slow-Wave Sleep (Delta-Sleep).
• Pregnenolone may increase Willpower.
• Pregnenolone enhances the function of the Amygdala, a part of the brain responsible for many aspects of Memory.
SEXUAL SYSTEM (Female)
• Supplemental Pregnenolone helps to alleviate the symptoms of Menopause.
• Pregnenolone may help to reduce the symptoms of Premenstrual Syndrome (PMS)
SKIN
• Applied topically, Pregnenolone helps alleviate Dry Skin.
• Oral Pregnenolone may benefit Psoriasis patients.
• Applied topically, Pregnenolone helps to retard Aging of the Skin.
• Applied topically, Pregnenolone alleviates Wrinkles.
USAGE
Pregnenolone is well absorbed both orally and topically. When taken orally, Pregnenolone should be taken first thing upon arising on an empty stomach. If you are using Pregnenolone topically for anything except wrinkles, be sure to rotate application sites for optimal absorption. Endogenous Pregnenolone production is circadian in nature so its best to take it all in a single morning dose. It takes approximately two weeks of daily dosing before the beneficial effects of Pregnenolone are realized.
When supplementing with any Bio-Identical Hormone(s) I always recommend that my clients monitor their hormone levels. In the case of Pregnenolone, at a minimum one should monitor both Pregnenolone Sulfate and DHEA Sulfate. If possible, one may also want to monitor Progesterone, Testosterone and Estradiol.
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